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| Passive | Arcane Mastery | | | | When Ryze casts a spell, all other spells have their cooldown reduced by 1 second. |
| Q | Overload | | 60 / 60 / 60 / 60 / 60 Mana | 3.5 / 3.5 / 3.5 / 3.5 / 3.5 | Active: Deals 60/85/110/135/160 (+0.4) plus 6.5/6.5/6.5/6.5/6.5% of Ryze's maximum Mana (+) in magic damage.
Passive: Gains 2/4/6/8/10% Cooldown Reduction. |
| W | Rune Prison | 600.0 | 60 / 70 / 80 / 90 / 100 Mana | 14 / 14 / 14 / 14 / 14 | Roots the enemy for 0.75/1/1.25/1.5/1.75 second(s), dealing 60/95/130/165/200 (+0.6) plus 4.5/4.5/4.5/4.5/4.5% of Ryze's maximum Mana (+) in magic damage. |
| E | Spell Flux | | 60 / 70 / 80 / 90 / 100 Mana | 14 / 14 / 14 / 14 / 14 | Unleashes an orb that bounces to enemies or Ryze up to 5 times.
Each bounce deals 50/70/90/110/130 (+0.35) plus 1/1/1/1/1% of Ryze's maximum Mana (+) magic damage and reduces Magic Resist by 12/15/18/21/24 for 5 seconds. |
| R | Desperate Power | | | 70 / 60 / 50 | Channels immense arcane power gaining 15/20/25% Spell Vamp, and 80/80/80 Movement Speed. Spells deal 50% area of effect damage for 5/6/ seconds. |