| | | | | |
| Passive | Deadly Venom | | | | Twitch's basic attacks infect the target, dealing true damage each second. |
| Q | Ambush | | 60 / 60 / 60 / 60 / 60 Mana | 16 / 16 / 16 / 16 / 16 | After 1.5/1.5/1.5/1.5/1.5 seconds of not taking damage or after 6/6/6/6/6 seconds, Twitch turns invisible for 4/5/6/7/8 seconds.
Twitch gains 20/20/20/20/20% Movement Speed while invisible and gains 30/40/50/60/70% Attack Speed for 5 seconds after coming out of invisibility. |
| W | Venom Cask | | 50 / 50 / 50 / 50 / 50 Mana | 13 / 12 / 11 / 10 / 9 | Twitch hurls a cask of venom that explodes in an area adding 2/2/2/2/2 stacks of Deadly Venom and slowing targets by 25/30/35/40/45% for 3/3/3/3/3 seconds. |
| E | Contaminate | | 50 / 60 / 70 / 80 / 90 Mana | 12 / 11 / 10 / 9 / 8 | Deals 20/35/50/65/80 physical damage plus 15/20/25/30/35 (+0.2) (+) per stack of Deadly Venom to all nearby enemies affected by Deadly Venom. |
| R | Rat-Ta-Tat-Tat | 1200.0 | 100 / 125 / 150 Mana | 120 / 110 / 100 | For 7/7/7 seconds Twitch gains 300/300/300 Attack Range, 20/28/36 Attack Damage and his basic attacks become piercing bolts that deal 20/20/20% less damage to subsequent targets down to a minimum of 40/40/40% damage. |